TNBC

Triple-negative breast cancer: a cancer defined by what it is not

Unlike other types of breast cancer, triple-negative breast cancer is defined by the absence of three receptors: it has no hormone receptors (estrogen and progesterone) and expresses little or no HER2 protein.

This means that certain targeted treatments that are effective in other forms of breast cancer do not work here. Treatment options are therefore more limited, but recent advances, such as ADCs and immunotherapy, are opening up new possibilities.

What is metastatic TNBC?

TNBC cells can break away from the original tumor in the breast and travel to other parts of the body, most often the bones, lungs, brain or liver. When this happens, it’s known as metastatic TNBC. Once the cancer has spread through the body, complete removal is unlikely. However, while this means the cancer may not go away completely, treatment can help.

About 9 11% of all breast cancer cases are triple-negative1
50 years and Under – TNBC is most common in premenopausal women under 50 years2
African origin – TNBC is more common in patients of African origin.2
Even in the absence of hormone receptors, medical advances now make it possible to better treat–and even cure–triple-negative breast cancer. The earlier it is detected and treated, the higher the chances of survival.
In the event of recurrence, triple-negative cancer returns with an average delay of 2.6 years. If triple-negative cancer does not recur in the first few years after treatment, the risk of recurrence decreases significantly after 5 years and becomes lower than for breast cancers that can recur much later.3
BRCA mutation - TNBC affects more patients with a BRCA mutations than other types of breast cancer2

Denise and Christelle are living with triple-negative breast cancer

Here, they share their journeys, their doubts, their strengths, and what helps them keep going every day. Their stories may inspire you or simply make you feel supported.

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When I was told I had triple-negative breast cancer, my world fell apart. I didn't know what it meant, but I understood that it was serious. My 5-year-old son was my strength. You can't give up on your child.

- Christelle, triple-negative breast cancer survivor.

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I felt a small lump in my breast, almost by accident. It was triple-negative breast cancer. The word was scary, and I didn't know what it meant.

- Denise, diagnosed with triple-negative breast cancer.

References
  1. Belgian Cancer Registry, facts and figures for 2019. https://kankerregister.org/
  2. Sharma P. Biology and Management of patients with triple-Negative Breast Cancer. Oncologist. 2016;21(9):1050-62
  3. Dent R, et al. Clin Cancer Res. 2007¹ and Foulkes, et al. N Engl J Med. 2010²

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